Publikationen

  1. DNAJC14-Independent Replication of the Atypical Porcine Pestivirus
    Reuscher CM, Seitz K, Schwarz L, Geranio F, Isken O, Raigel M, Huber Th, Barth S, Riedel Ch, Netsch A, Zimmer K, Rümenapf T, Tautz N, Lampa B 2022 J Virol Aug; 96(15): e01980-21. Published online 2022 Jul 19. doi: 10.1128/jvi.01980-21

  2. Identification of NS2 determinants stimulating intrinsic HCV NS2 protease activity
    Isken O, Walther Th, Wong-Dilworth L, Rehders D, Redecke L, Tautz N 2022 PLoS Pathog. 2022 Jun; 18(6): e1010644. Published online 2022 Jun 21. doi: 10.1371/journal.ppat.1010644

  3. A novel NS3/4A protease dependent cleavage site within pestiviral NS2.
    Walther T, Bruhn B, Isken O, Tautz N. 2021 J Gen Virol Oct 102 (10). doi:10.1099/jgv.0.001666.

  4. Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication.
    Flory C, Chan KWK, Bifani AM, Choy MMJ, Lescar J, Ooi EE, Tautz N, Vasudevan SG. 2021 Antiviral  Res. Nov 195:105194. doi: 10.1016/j. antiviral2021.105194

  5. Membrane Topology of Pestiviral Non-Structural Protein 2 and determination of the minimal autoprotease domain.
    Walther T, Fellenberg J, Klemens O, Isken O, Tautz N. 2021 J Virol Mar 17:95(11). doi: 10.1128/JVI.00154-21.

  6. Porcine Complement Regulatory Protein CD46 Is a Major Receptor for Atypical Porcine Pestivirus but Not for Classical Swine Fever Virus.
    Cagatay GN, Antos A, Suckstorff O, Isken O, Tautz N, Becher P, Postel A. 2021 J Virol. Apr 12;95(9):e02186-20. doi: 10.1128/JVI.02186-20.

  7. Development of a High-Throughput Serum Neutralization Test Using Recombinant Pestiviruses Possessing a Small Reporter Tag.
    Tetsuo M, Matsuno K, Tamura T, Fukuhara T, Kim T, Okamatsu M, Tautz N, Matsuura Y, Sakoda Y. 2020 Pathogens Mar 4:9(3):188. doi: 10.3390/pathogens9030188.

  8. Determination of critical requirements for NS2-3-independent virion formation of classical swine fever virus.
    Dubrau D, Schwindt S, Klemens O, Bischoff H, Tautz N. 2019 J Virol Jul 10. pii: JVI.00679-19. doi: 10.1128/JVI.00679-19.
     
  9. CRISPR/Cas9-Mediated Knockout of DNAJC14 Varifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses.
    Isken O, Postel A, Bruhn B, Lattwein E, Becher P, Tautz N. 2019 J Virol Feb 19;93(5). pii: e01714-18. doi: 10.1128/JVI.01714-18. Print 2019 Mar 1.
     
  10. Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag.
    Tamura T, Fukuhara T, Uchida T, Ono C, Mori H, Sato A, Fauzyah Y, Okamoto T, Kurosu T, Setoh YX, Imamura M, Tautz N, Sakoda Y, Khromykh AA, Chayama K, Matsuura Y. 2018 J Virol an 2;92(2). pii: e01582-17. doi: 10.1128/JVI.01582-17. Print 2018 Jan 15.
     
  11. A positive strand-RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication an virion morphogenesis.
    Dubrau D, Tortorici MA, Rey FA, Tautz N. 2017 PLOS Pathogens/Doi: 10.1371/journal.ppat.1006134 dazu: "Wie Viren ihren Lebenszyklus sicherstellen."
     
  12. Adressing the next challenges: A summary of the 22nd international symposium on hepatitis c virus and related viruses.
    Baumert TF, Schuster C, Cosset F-L, Dubuisson J, Hofmann M, Tautz N, Zeisel MB, Thimme R. 2016 Journal of Hepatology Vo. 64: 968-973.
     
  13. A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication.
    Isken O, Langerwisch U, Jirasko V, Rehders D, Redeke L, Ramanathan H, Lindenbach BD, Bartenschlager R, Tautz N. 2016 PLoS Pathog e: 1005394. doi: 10.1371/journal.ppat.1005394
     
  14. Polyprotein-Driven Formation of Two Interdependent Sets of Complexes Supporting of Hepatitis C Virus Genome Replication.
    Gomes RG, Isken O, Tautz N, McLauchlan J, McCormick CJ. 2015 J Virol 90: 2868-83.
     
  15. Characterization of the Determinants of NS2-3-Independent Virion Morphogenesis of Pestiviruses.
    Klemens O, Dubrau D, Tautz N. 2015 J Virol 89: 11668-80. doi: 10.1128/JVI.01646-15 Epub.
     
  16. The Molecular Virology of Pestiviruses.
    Tautz N, Tews BA, Meyers G. 2015 Adv Virus Res. 93: 47-160.
     
  17. Functional Characterization of Bovine Viral Diarrhea Virus Nonstructural Protein 5A by Reverse Genetic Analysis and Live Cell Imaging
    Isken O, Langerwisch U, Schönherr R, Lamp B, Schröder K, Duden R, Rümenapf TH, Tautz N. 2014 Journal of Virology 88: 82-98.
     
  18. Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3.
    Lattwein E, Klemens O, Schwindt S, Becher P, Tautz N. 2012 Journal of virology 86:427-37
     
  19. RNA recombination in pestiviruses - cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease.
    Becher P and Tautz N. 2011 RNA Biol 8:216-24.
     
  20. Basic science paves the way to novel safe and effective pestivirus vaccines.
    Tautz N and Meyers G. 2010, pp 173-193 in: Replicating Vaccines - A New Generation by Dormitzer PR, Mandl CW, Rappuoli R (Editors). Springer Basel AG 2011.
     
  21. HCV Research 20 Years After Discovery: A Summary of the 16th International Symposium on Hepatitis C Virus and Related Viruses.
    Pawlotsky JM, Cocquerel L, Durantel D, Lavillette D, Lerat H, Pécheur EI, Polyak SJ, Tautz N, and Thimme R. 2010. Gastroenterology 138(1):6-12.
     
  22. The pioneer round of translation: features and functions.
    Maquat LE, Tarn WY, Isken O. 2010. Cell, Aug 6, 142 (3):368-74.
     
  23. Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A.
    Ciesek S, Steinmann E, Wedemeyer H, Manns MP, Neyts J, Tautz N, Madan V, Bartenschlager R, von Hahn T, and Pietschmann T. 2009. Hepatology. 50(5):1638-45.
     
  24. Hepatitis C virus NS2-3 protease - NS2 is a bona fide protease stimulated by cofactor domains in NS3.
    Schregel V, Jacobi S, Penin F and Tautz N. 2009. Natl. Acad. Sci. USA 106: 5342-7.
     
  25. The multiple lives of NMD factors: balancing roles in gene and genome regulation.
    Isken O, Maquat LE. 2008. Nat Rev Genet. 2008. 9:699-712.
     
  26. Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.
    Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE. 2008. Cell 133:314-27.
     
  27. Cytopathogenicity of classical Swine Fever virus correlates with attenuation in the natural host.
    Gallei A, Blome S, Gilgenbach S, Tautz N, Moennig V, Becher P. 2008. J. Virol. 82: 9717-9729.
     
  28. Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis.
    Lackner T, Thiel H-J, Tautz N. 2006.Proc. Natl. Acad. Sci. U S A. 103 (5): 1510-5.
     
  29. Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease.
    Lackner T, Müller A, König M, Thiel H-J, Tautz N. 2005. J. Virol. 79: 9746-9755.
     
  30. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus.
    Lackner T, Müller A, Pankraz A, Becher P, Thiel H-J, Gorbalenya A E, Tautz N. 2004.J. Virol. 78:10765-10775.
     
  31. Functional importance of the N terminus of NS3 for replication of pestiviruses.
    Tautz N, Thiel H-J. 2003.Arch. Virol. 148: 1405-12
     
  32. Cell-derived sequences located in the structural genes of a cytopathogenic pestivirus.
    Müller A, Rinck G, Thiel H-J, Tautz N. 2003. J. Virol. 77: 10663-10669.
     
  33. A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus.
    Rinck G, Bighan C, Harada T, Meyers G, Thiel H-J, Tautz N. 2001. J. Virol. 75: 9470-9482.
     
  34. NS3 serine protease of bovine viral diarrhea virus: Characterization of active site residues, NS4A cofactor domain, and protease-cofactor interactions.
    Tautz N, Kaiser A, Thiel H-J. 2000. Virology 273:351-363.
     
  35. Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons. 
    Tautz N, Harada T, Kaiser A, Rinck G, Behrens S-E, Thiel H-J. 1999. J. Virol. 73:9422-9432.
     
  36. Characterization of an autonomous subgenomic pestivirus RNA replicon.
    Behrens S-E, Grassmann C W, Thiel H-J, Meyers G, Tautz N. 1998. J. Virol. 72:2364-2372.
     
  37. Serine protease of pestiviruses: determination of cleavage sites. 
    Tautz N, Elbers K, Stoll D, Meyers G, Thiel H-J. 1997. J. Virol. 71:5415-22.
     
  38. Cytopathogenicity of a pestivirus correlated with a 27 nucleotide insertion.
    Tautz N, Meyers G, Stark R, Dubovi E J, Thiel H-J. 1996. J. Virol. 70:7851-7858.
     
  39. Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by internal deletion.
    Tautz N, Thiel H-J, Dubovi E J, Meyers G. 1994. J. Virol. 68:3289-3297.
     
  40. Processing of poly-ubiquitin in the polyprotein of an RNA virus.
    Tautz N, Meyers G, Thiel H-J. 1993. Virology. 197:74-85.


Review article and Book contribution

  • Pawlotsky JM, Cocquerel L, Durantel D, Lavillette D, Lerat H, Pécheur El, Polyak SJ, Tautz N, Thimme R (2009): HCV Research 20 Years After Discovery: A Summary of th 16th International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology.
     
  • Tautz N, Thiel H-J (2008): Molekulare Pathogenese der Mucosal Disease. Nova Acta Lepoldina NF 95, Nr. 350: 23-35.
     
  • Tautz N, Thiel H-J. Molekulare Pathogenese der Mucosal Disease. Nova Acta Leopoldina N. F. Bd. 94, Nr. 353. Zur Rolle der Veterinärmedizin in Forschung und Gesellschaft. Herausgegeben von Hartwig Bostedt (Gießen), Leo Brunnberg (Berlin), Johannes Eckert (Zürich), Theodor Hiepe (Berlin) und Holger Martens (Berlin). Symposium der Deutschen Akademie der Naturforscher und der Veterinärmedizinischen Gesellschaft am 13. und 14. Oktober 2006 in Berlin.
     
  • Tautz N, Thiel H-J. 2004. Pestivirus NS2-3/NS3 serine peptidase. In A.J. Barrett an N. D. Rawlings and J.F. Woessner (ed.), Handbook of proteolytic enzymes. Second Edition. Academic Press, p. 1781-1784.